Real Madrid's squad for the Clasico on Wednesday

Barcelona forward Lionel Messi

Barcelona president Josep Maria Bartomeu says that he is open to negotiating terms with Real Madrid chief Florentino Perez for out-of-favour attacker Isco. "On the left wing, Vinicius is playing well and Bale has his difficulties", Mijatovic told Cadena SER . "If Messi's ready he will play, if he's not he won't". Barca have indicated they will not risk their captain with a gruelling month ahead.

Real in particular, need to keep an eye on the league - where they sit third, eight points adrift of leaders Barcelona - and face a Madrid derby against second-placed Atletico at the weekend.

Messi has scored in nine straight games in all competitions, and is La Liga's leading scorer with 21 in 22 matches.

Messi was out with a broken arm the last time Spain's two biggest clubs met back in October.

He is very important for the team as some of the results of the team without him prove, but let's not forget Barcelona have beaten Real Madrid by 5-0 this season in his absence.

Now, they are looking to end FC Barcelona's run of four consecutive Copa del Rey triumphs. However, he completed Tuesday's session and has been named among the 19 players called up for the first leg of the semifinal tie at Camp Nou.

There are also selection issues at Madrid, with Solari likely to include either Gareth Bale or Vinicius Junior in his attack alongside Karim Benzema and Lucas Vazquez.

Barcelona's preparation for the Copa del Rey semi-final opener have been marred by a mini injury crisis which has seen Ousmane Dembele, Jasper Cillessen, Samuel Umtiti and Rafinha all ruled out.

Messi is part of Barcelona's squad and is available for the game, but it's unclear if he'll play against Real Madrid. The French striker has 18 goals, six more than he had in all of last season. Asked about the fitness of Messi, he said: "It's always better when the best players get to play, it's as simple as that".

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